I have a Dell Laptop Inspiron 9300. MS XP. USB Belkin Wireless mouse and Targus wired mouse are both suddenly malfuntioning. (No they are not connected at the same time.) I am an IT guy, working with a bunch of other IT guys, and none have heard of this type of malfunction until I showed them. The below applies to both mice. Cursor can be moved around fine. I can click on a desktop folder and open it - but then clicking on the X doesn't close it. Right clicking on folder in toolbar does nothing. Folders on desktop can be highlighted but not moved, file snaps back to where it was. NO I DON'T HAVE THE DESKTOP LOCKED, AUTO ARRANGE OR ALLIGN TO GRID CHECKED. I have even gone in to regedit and confirmed the hexadecimal settings are "no auto arrange", "no allign to grid". After a couple folders are opened, nothing else can be opened including START button. Forced reboot is the only escape. When I start the system I can use the touch pad with no problems, desktop icons can be moved around, folders can be opened and closed. Once I insert a USB mouse, the touch pad malfunctions like stated above. Even removing the mouse doesn't restore the mouse pad functionality. That really seems strange. I have tried both mice in multiple USB ports on the system. Is this a driver issue? Both mice were plug and play. I used the Targus wired mouse with no problems for 9 months and then upgraded to the wirless mouse a month ago - with no problems until 2 days ago. Could friggin Itunes be somehow screwing this up? I mention it only because my Itunes is jacked up also, giving error messages when I attempt to update it. I have reinstalled and attmpted repair of the newest Itunes 7.0 to no avail. But that's a question for the Apple website. I just want my mouse to work.