Computer gets stuck if I open any application

So the computer starts ok but if I go to the start menu and open microsoft word for instance, the computer just gets frozen. That waiting "i am frozen" sign just stays there nothing opens and nothing happens.

I have tried logging in to other users and same thing

I have tried to run the computer in safe mode (without networking) and i can run everything okay but obviously i am limited to what i can do.
 
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