I tried to google this, I came up with: a ton of crap about beta versions of Vista, a post on cnet saying yes, a post on cdrinfo saying no, and a download on afterdawn listing Vista in the OS list. So basically, inconclusive. I can install it and find out, but I am always reluctant to install stuff like that because I'm not convinced that uninstalling it removes everything. Installing Nero 7 is an option I'd like to avoid because I bought Nero 6 and would like to keep using it. If it comes to buying Nero 7 I may just skip that alltogether and use Vista's built in capability, and hope that something like CDBurnerXP Pro works with Vista.