I started to see lock ups on my XFX after 400/1.1. Admittedly I am not a O/Cing guru and I am sure that if you know what you are doing and have the right cooling, you can get it higher but I have been satisfied at those numbers with my SLI rig.
I had to go NV5 as the two 6800GT cards, CPU, 2HDD and 2GB of RAM, all stuffed into a Lian-Li PC60A Plus and overclocked, created huge amounts of heat and the resultant problems. The NV5 is great because it not only cools better than stock but dumps the GPU heated air outside the case rather than into it (takes up 2 full PCI slots though). This cooled off not only my 6800GT's but the CPU as well, since case temperatures dropped dramtically.