I just bought a Gigabyte GA-8INXP motherboard and got it assembled. I have 1GB of 266MHz DDR RAM, 120GB Western Digital HD and a 2.53GHz Pentium running Windows XP Professional. I have a Microsoft Wireless Intellimouse Explorer (USB 1.1) and a Microsoft Sidewinder 2 Joystick (USB 1.1) connected. I'm using a Logitech keyboard connected via a standard PS/2 connector. I have also experienced this problem with the joy stick. I have unplugged the joy stick and still get the same problem with the mouse. Every since I turned the system on (over 3 weeks ago) I've been experiencing mouse "lockups". By lockup I mean it stops responding. The keyboard continues to respond but the mouse stays locked up and won't return. If I unplug it from the USB connector and plug it back in, it works fine again for a while. The amount of time between lockups varies from 2 hours to 3 minutes. I've checked the Microsoft website for mouse drivers and installed them. I checked the Gigabyte website for USB drivers and installed both set listed there. I still have the same problem. Has anyone else experienced this problem? Any ideas on how to fix it? I'm about ready to return this mbo to newegg.com and get a new one.