I'm with SNGX, if it's used frequently just leave it on.
I could be wrong on this, but I believe most of today's HDDs automatically perform a task known as "disk sweep" or "wear leveling". The procedure occurs after a brief idle time, where the read/write heads are moved to a cylinder in the outer portion of the platters. If activity remains idle for another period of time, the read/write heads move to another cylinder in the same vicinity.
The technology is supposed to prevent the platters from extended exposure to the friction caused by the read/write heads. While the heads are not in direct contact with the medium, they are close enough that the constant air pressure from the floating heads will increase wear and potentially cause complications over time.
Odds are, your HDD will be obsolete and put out of commission before it experiences any issues, so, just let it go.