Hijacked with malware and trojans and cannot log on in safe mode

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After visiting a site popups indicated I had all kinds of infections and wanted me to download a program. I did not download the program but instead ran softis anti virus software. It found and quarantined two malware programs but told me to run a full scan (which I had already done) to remove the trojan. The computer then restarted windows and I was not able to log on to a user. I tried to restart in safe mode and it still will not let me log on as a user. Any ideas of how I can get my comoputer clean?
 
is it ok with you if you have to format hard drive

thats the only way i seem to get out of this mess.
You will lose all your important files though.
 
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