Well I've tested it on 4 PCs desktops and laptops I didn't see any problems using the produce with my own AV.
1. Spyware Terminator
2. Spyware Blaster
I would only run these two once and just update Spyware Blaster when needed. Spyware Terminator does have on-demand mode so it can protect the system. That works. I've tested a lot of software, but since this one was free I would suggest those to try it out. You can always remove it and try another one..