I recently updated my sound card drivers for my Creative SB Audigy LS. The next day I started having issues with my microsoft optical mouse (5 button). In video games it would randomly fail. The red light woudl just go off. Gone. No mouse input. The keyboard was fine, the sound was fine, the video was fine, everything was fine except the mouse. I looked on some forums, they indicated sharing IRQs of the mouse and the sound card/video card could be the culprit. I checked IRQs of devices and sure enough my onboard usb hubs share an IRQ with the sound card AND the video card. So i used the usb hubs that didn't. (I have 8 ports in all.) Nothing worked. So I fiddled around as best I could with the IRQ settings, moved the sound card into a new PCI slot, removed all drivers for mouse, video, and sound, and everything went smoothly. Now it starts happening randomly while not in video games too! So i made the problem worse. Maybe I didn;t set IRQs in BIOS correctly. Maybe My mouse is dead. I have not tried getting a ps/2 adapter, nor have I tried other mice. I dont have access to either one of those at this point in time. Anyone have any suggestions as to how to fix my situation? I'm sure it is a configuration issue, but I can't seem to get it right.