Sequels seem to be the fad right now, with Soldiers of Fortune 2, Jedi Knight 2, Unreal 2, UT 2, Doom 3, Warcraft III, Icewind Dale 2, Thief 3, Deus Ex 2 etc. in the works, but where is System Shock 3? I never played the legendary original, but SS 2 is one of the most terrifying and atmospheric games I've ever played. It also succeded admiringly to fuse RPG-elements with a FPS. The downside was the lackluster graphics as it was built with the Thief-engine. The atmosphere, depth, gameplay and cinematic storyline of SS2 combined with the Doom 3 or Unreal 2-engine would surely be unbeatable. So that's my pick for the most wanted (and missing) sequel.