Follow the instruction manual that came with the board. Just because a motherboad comes with lots of cables and accessories (depending on the model) doesn't necessarily mean you need to connect them all. Some come with extra pci cards for additional USB connections; some come with firewire ports, etc. Some are also dependent upon your case as well. If the case has a built in firewire port, then instead of connecting a firewire port pci card, connect the cable to the case and ensure it's connected to the correct pins on the motherboard (assuming the board supports it). Did you purchase the Deluxe or Premium version of the board? Personally, I've never connected the game/midi port cable since I use gamepads/joysticks that connect to a 2.0 USB connection.