Mouse freezing in and out of safe mode

[Artist12682]

Gateway GM5661e
Windows Vista Home Premium
Intel® Core™2 E4500 dual core processor
•Installed: 3072 MB DDR2, 667 MHz, (PC2-5300) dual channel memory
500 GB, 7200 RPM, SATA II hard drive

All appears normal, but after touching the mouse the problems are apparent. The mouse freezes all over the screen. I have to do a large sweep and then tiny micro-movements to select and icon. The programs load super slow and the mouse is skipping all over the screen. When the Pc is turned on the gateway screen is on for over a minute then the monitor turns off and then back on the loading bar pauses many times as it starts up. It eventually loads, but then the mouse doesn't move. The pc makes a grinding, clicking sound when the mouse moves, but then the mouse freezes and the noise stops. I am at a loss for words. I have been through a lot with this pc from last month when it stopped turning on. It has come a long way and I feel like it am almost done, but something isn't right. I am hoping it is not the motherboard, but I cannot think of anything else it could be.

These are the steps i have taken to fix my pc.

Checked PC to make sure drivers were up to date.
Defragged the hard-drive
registry cleaner
Removed all dust
replaced thermal paste on cpu
Did a recovery that formatted the hard drive and reinstalled the OS
Installed Antec PSU
Replaced CPU Fan
Opened safemode and mouse still freezes

It seems that as soon as the Pc starts the problem is already at work. It all started after I install some phone software, but after the format I would think if it was a software issue it would have been resolved.
Thanks for any help you can offer.

 

[Mark56]

First I would advise you never use a registry cleaner unless you know exactly what it is removing, they can do more harm than good.

My first thought is that your hard drive may be failing so please follow this guide to run the manufacturer's diagnostics.

Identify the make of your hard drive and then use one of the links below to get the manufacturers diagnostic for ISO CD. Burn the image file to a CD, boot the PC with the disc in the drive and run the diagnostics. You first need to set the CD drive to 1st in the boot order in the Bios setup.

If you do not have an image burner use this free software to make the CD.

http://www.isoimageburner.com/



ExcelStor: http://www.excelstor.com/eng/support.php?sub_id=3

Hitachi/IBM: http://www.hitachigst.com/support/downloads/

Samsung: http://www.samsung.com/global/business/hdd/support/downloads/support_in_es.html

Seagate, Maxtor & Quantum:http://www.seagate.com/www/en-us/support/downloads

Western Digital:http://support.wdc.com/product/download.asp?lang=en

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Toshiba Fujitsu: http://sdd.toshiba.com/main.aspx?Path=SoftwareUtilities#diagnostic

If you have a Toshiba hard drive I would suggest the use of the diagnostics from the Seagate link as this will work on all makes of drive and on any OS.