You should never change the 2D clocks because they are only used while doing non-3D operations such as surfing the internet or checking your e-mail. 3D clocks take over as soon as the video card is called upon to do operations.
If you want to overclock, use the 3D core and memory clocks and raise them about 4-5MHz at a time until you get to the point where either you start getting artifacts (objects on the screen that are not supposed to be there, such as dots or fuzz) or your system freezes. Once you get to that point, start going down 1-2MHz again until you find a stable clockspeed to work with.
Take note that not every application might work with one clock speed. You may have to try and re-try to find a speed that will work with every game or application.