Lots of popups, task manager not working and many other programs not working

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Hi, I'm wondering if anyone can help me, my computer has lots of popups, the broweser keeps moving of it's own accord and loading up. Hijack this will only work in safe mode, and generally the system won't run things. I've run adaware, CWshredder, AVG, zonealarm won't load because of true vector already running and i can't get rid of that as task managed won't work :-/ msconfig and regedit won't work.I've tried going through many of the guides on here,but it doesn't seem to make much of a dent

This is the hijack log i got whilst running in safe mode.
 
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