Keyboard / Mouse Mouse spases to bottom left and clicks

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I've had this problem for about a month now, but here is my problem: Everyone once and a while my mouse moves into the bottoom left corner and starts to left and right click 100 times a sec on its own. Whenever I try to move the mouse, it spases around my screen, left and right clicking and closing anything I have open. Could this be a mouse problem? Or a virus? I've done the Trend Micro Housecall virus scan, and found nothing, same with spybot/adaware/scandisk. Any help? It happens when I'm at the desktop, and in games and I get accused of hacking because I start to violently spin around..

Any help?
 
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