I would agree with Grok, if you've never been inside there before changing things around, you're in for it. The motherboard manual won't really explain what to do with all your other parts once you remove it all.
We would charge $60 to install and test your new board at our shop, not including software work. So it may not be that bad to have someone do it. But then if it's a different board you WILL want to backup your data and reload like he said.
Good luck with that project!