VirtualBox has an extremely modular design with well-defined internal programming interfaces and a client/server design. This makes it easy to control it from several interfaces at once: for example, you can start a virtual machine in a typical virtual machine GUI and then control that machine from the command line, or possibly remotely. VirtualBox also comes with a full Software Development Kit: even though it is Open Source Software, you don't have to hack the source to write a new interface for VirtualBox. Learn more.