Bad MotherBoard

I have a PC that locks the keyboard and mouse while booting up. I am loading Windows XP to a new hard drive. I have elimiated memory problems and hard drive problems by replacing the old ones. Could this be a mother board issue or a different problem?
 
Hey Sam, Welcome!

Can you give me some computer specs? What is the system (Make, model, CPU type, memory amount, motherboard model?)
 
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