Some programs like regedit, msconfig, hijackthis, regcleaner, and antivirus sites like the trendmicro.com and symantec.com won't work. (i can still run trendmicro on their european website) Suprisingly taskmananager still works. The programs that doesn't work open up for a few seconds and closes up by itself. Sometimes it won't open, sometimes you would see the program flash open and go out by itself again, and sometimes it can stay for a max of 5 seconds but no longer. I was able to open HJT just long enough for it to complete scanning, at the same time I was able to open msconfig while it was scanning. Hope that helps.