Yes but if it boots in Safe Mode problems solved. Reboot and it will update all drivers. This also works for drives cloned with DriveImageXML*** and used on a different PC of different spec. If not I'll just do a fixboot, fixmbr and bootcfg on the Recovery Console.
[add'l]
Been there done that on Intel, not successful with AMD though.
*** I you restore let's say a 20 gig image to a 100 gig drive perform a CHKDSK on the 100 gig.