Yes. If it is an OEM version, you will need to re-register it, but if you do it by telephone, there should be no problem whatsoever... You just tell them what happened, or tell them you are moving that Windows XP version to another hard drive that is better, faster, whatever, or that the old one died... You won't need to uninstall the old drive, but it will only work on that computer... and if you move the drive to another machine, you will likely have to re-register it, and that is when they will refuse.