Explorer.exe keeps restarting and won't boot into safe mode

Hi everyone i hope someone can help.

My computer came up with the following message this morning

windows no disk

exception processing message c0000013 parameters 75b6bf7c 4 75b6bf7c 75b6bf7c

when i clicked cancel the computer kept flashing!

I restarted the computer and the computer started flashing again!
When i went into task manager i noticed that the "flashing" was being caused by explorer.exe keep restarting.

I went into msconfig and selected the /safeboot option to start windows in safemode and now the computer just keeps restarting when it reaches the windows loading screen!

Any help would be much appreciated

Thanks Chris

Flashing GUI

What version of Windows do you have?

If you have Windows 7 and you updated your video driver, that can be it right there. If that's the problem, then you might have to roll back your updates and go back to your former ones.