Yes. I have a two monitor set up, (with an "extended desktop")
One I have in portrait, the other in landscape.
These are primarily for desktop publishing purposes.
Sometimes I want to view my work one way, sometimes the other.
I had always wondered how anyone would like it for gaming.
Seems to me the movement between screens, and breaks in field of vision could be issues.
But, I am not a gamer, so what would I know.
Cons? for me?
Holding my neck / head in one position for extended periods ,
other than a centered/neutral position,
can result in some neck pain.
Solution is to compensate by how I position myself,
and using the dual monitor stand's full ability to tilt, swivel etc.
Younger persons may not notice the issue as much.
I cannot imagine how I would use a set up with more than two monitors though.
This stand has been excellent for my purposes.
They also make a
four monitor (2x2) version,
and I have seen stands where you can
mount 3 monitors side by side.
By the way this set up is used alternately with..
a) Dell Vostro 3550 Laptop (has an i3 processor, and both HDMI and VGA out)
b) On board graphics with a Gigabye GA-Z77X-UD5H (has two HDMI, plus DVI, plus VGA)
So, no fancy graphics card setups here!