You will be doing yourself a favor if you uninstall Spybot if it is 1.30 or before... It simply does not have the power to do battle with real infestations... it is basically a cookie cleaner.
Suggest you run a scan with Avira after updating it, then SuperAntiSpywre and MalwareBytes, as well as Windows defender.
You can lave McAfee on there but do not run it, until after you have the results of Avira... then you will know if it is doing the job.