USB Mouse\keyboard dead

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I was forced to reload XP Pro on my SX280. When I loaded SP2, the USB Mouse and the keyboard went DEAD! I tried to load SP3, but wouldn't load. I used the microsoft update site for both SP2 & SP3 Without the mouse or keyboard I'm limited on what I can do. Help!!!!

The system is Dell Optiplex SX280 Bios A09
USB mouse & keyboard
Windows XP Pro
 
No, not in safe mode. I did reload windows in the repair mode, then I down loaded SP2 without reboot, and updated the Bios to the latest revision. Then I rebooted. I did not lose my USB ports this time. I am going to trry to update windows to SP3 now without losing my USB ports. I'm keeping my fingers crossed! Thanks. Docjsj
 
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