Hi, This problem has been driving me mad. Its happened a good 3 times now and ive just given up and formatted before. Now it keeps coming back its time to knuckle down and find the problem. Computer setup is as follows: Windows XP pro, all updates installed System very regularly scanned for spyware, am running all of the following: Adwatch, Adaware, Microsoft Antispyware, Spybot S+d, Wintasks 5 pro. Basically upon windows starting adwatch window will show some attempted changes in the registry. They basically look like the normal values are trying to be put back, eg internet start page. Nothing actually hijacks internet use. However no programs will run atall, and everytime i click on a program, eg hijackthis the icon changes to the 'hidden' style seethrough. At this time my firewall (kerio personal 5) is still running, as is microsoft antispyware. Microsoft one wont respond though. I cannot open hijack this or anything else to post a log here. I have tried using an online scanner 'Panda' but the window doesnt stay open for more than a second (having to use internet explorer rather than my usual firefox, because its all that is supported) From previous experience after one or 2 more reboots nothing will be running in the taskbar, and all the icons will go blank, with the .ink extension after them. One or two reboots again will completely screw up and windows wont even load. Any help very much appreciated.