Sure they are..., especially if its not an old one.
Check the chosen distro site, search for your board's model and/or chipsets.
The best distro for you depends on what are you gonna use your OS/PC for...
If you are a professional looking to train yourself on Linux for a production environment etc, get Debian, Centos, Suse.
Or even you may want to try with BSD (non linux, still unix like systems)..., FreeBSD or OpenBSD the best choices.
If you are not a pro and just want to mess around get Ubuntu or Fedora.
Good luck.
D.