Block "iexplore.exe" system wide so it cant be ran at all?

i know how to block IE from being ran for each user in the reg key
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer\DisallowRun]
"1"="iexplore.exe",
but some programs use IE Embeding COM interacting
"C:\Program Files\Internet Explorer\IEXPLORE.EXE" -Embedding" for their programs..
and when you encounter a webpage that contains web-code to trigger an IE popup the popup occurs in a new instance of "iexplore.exe" which gets started from a system svchost.exe process and even if you have that above reg key installed it doesn't block the the new instance of "iexplore.exe" which displays the IE popup..

So i was wondering if there were some way to block "iexplore.exe" in a system wide scope from being ran at all with a reg key or somthing..??