Hard disk shows full in normal startup but correct in safe mode

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\spoolsv.exe
C:\Program Files\Common Files\Seagate\Schedule2\schedul2.exe
E:\Program Files\APC\APC PowerChute Personal Edition\mainserv.exe
C:\Program Files\Memeo\AutoBackup\MemeoService.exe
C:\Program Files\Google\Common\Google Updater\GoogleUpdaterService.exe
C:\Program Files\Google\Update\GoogleUpdate.exe
C:\Program Files\Common Files\InterVideo\RegMgr\iviRegMgr.exe
C:\Program Files\Java\jre6\bin\jqs.exe
C:\Program Files\Common Files\LightScribe\LSSrvc.exe
C:\Program Files\McAfee\SiteAdvisor\McSACore.exe
C:\PROGRA~1\McAfee\MSC\mcmscsvc.exe
c:\PROGRA~1\COMMON~1\mcafee\mna\mcnasvc.exe
c:\PROGRA~1\COMMON~1\mcafee\mcproxy\mcproxy.exe
C:\Program Files\McAfee\MPF\MPFSrv.exe
C:\Program Files\McAfee\MSK\MskSrver.exe
C:\Program Files\Nero\Nero8\Nero BackItUp\NBService.exe
C:\WINDOWS\system32\nvsvc32.exe
C:\Program Files\Common Files\Protexis\License Service\PsiService_2.exe
C:\Program Files\Microsoft\Search Enhancement Pack\SeaPort\SeaPort.exe
c:\PROGRA~1\mcafee.com\agent\mcagent.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe