Sagispul Infection and possibly more

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My PC has slown down considerably since the weekend. Now I'm receiving pop ups and particularly a pop up with a "sagispul" link. Also I receive a error stating that IE has experienced an error w/ option to send or do not send even though I recentlly began using Firefox as my default browser. I've run a full McAfee virus scan (w/ no luck) and full Spyware Doctor scan. I've run the spyware scan multiple times and each time I run it, I keep finding additional infections w/ no improvement in my systems performance after making the fixes. Where should I start? Thanks.

-Cliff
 
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