Strange problem...

Hi everybody.

A friend of mine has the following strange problem:
His Win XP Pro machine (in a domain), some random minutes after starting begins acting weirdly.
That is, if you open an app, and the, you minimize or close it, the action performs correctly, BUT, the desktop remains "drawn" as if the window was still on the desktop.
The desktop functionality also disappears; you cannot use anything from the desktop.
Of course you can use the icons from the desktop if you open the windows explorer.
BUT you can only open Windows explorer by pressing Win + E.

That PC has Panda endpoint protection

What I did was:

Combofix
malwarebites antimalware
JRT
aswMBR
tdsskiller
Roguekiller
adwcleaner
GMER

The system came up clean

I also did Memtest86+ - Memory test OK
Disk check with manufacturer diagnostic utility (Seagate) - Disk OK
sfc /scannow - just in case something was altered

Any ideas are very welcome.

Thanks
 
Configuration is as follows:
2 * 1 GB DDR2
Core 2 Duo E2160
Asus P5GC-MX/1333 Mobo
320 GB Seagate HDD
Nvidia Geforce GTX 275
 
This is exactly what I have in mind right now:
- video driver uninstall
- driver sweeper from safe mode
- reboot in normal mode
- latest available video driver reinstall
 
Hello,
I'm back, with final report.
After uninstalling the video driver, and running Driver Sweeper, and making a clean latest Nvidia driver re-install, I noticed the problem was still there.
After a paying a little bit more attention, I discovered that the problem only appeared AFTER opening IE, closing it and then RESTARTING IE.
I realized that iexplore.exe did not terminate properly.
After closing the IE window, there were 2 more instances of it in task manager.
Finally, after disabling Skype add-on, everything came back to normal.

Case closed.
Thanks everyone for all the ideas.
 
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