Physical size won't matter. If it something like a Radeon HD 6870, then it might have something like 2 DVI, 1 HDMI, and 2 DiplayPort (mini). So you could easily connect two monitors, either to the DVI or the DisplayPort sockets; they don't have to be on the same socket (so you could have 1 DVI and 1 DP).
However, you are limited to what resolution can be run on the ports:
https://bit-tech.net/reviews/tech/graphics/ati-radeon-hd-6870-review/3/
This suggests that going with two modern, high resolution large monitors on DVI isn't worth it, and that you'll need to use the DP sockets.
Edit:
Here's a bit more on connecting monitors:
https://www.guru3d.com/articles-pages/radeon-hd-6850-6870-review,4.html
https://www.amd.com/en/support/driverhelp#paragraph-125741