iTunes users beware, the current versions of iTunes are incompatible with Vista, and could result in you not being able to play your music, among very odd behavior from the program itself. As the notice states, Apple is quite aware of the problems, and has posted a rudimentary workaround for some of them, though an actual fix that will give people a straight upgrade path has not yet been posted. They have, however, created a repair tool specifically for Vista that will attempt to fix it.