Stores aren't even done stocking their shelves with the first pallets of GTA IV boxes, and yet there are already protests rolling in against the game. One of the first such protests is coming from MADD (Mothers Against Drunk Driving), who claim the game endorses drunk driving. The group is demanding that the Electronic Software Ratings Board re-rate the game, giving it an "Adults Only" rate, a request that by itself is actually very reasonable. However, a second one asks Rockstar to consider a "stop in distribution," which is not hard to anticipate will not happen.
With every GTA release, Rockstar has in its hands some of the most anticipated and lucrative games of all time, and this is certainly not the first nor the last protest against the series.