I am running Windows 7 64-bit edition, and use Microsoft Security Essentials and have several instances of iexplore.exe and svchost.exe that spawn automatically after logging in, without launching any application (namely IE). I keep my OS and (frequently used, anyway) software and drivers up-to-date with security updates. Recently, (I relate this to updating Adobe Flash Player after a restart forced by installing MS critical updates and iTunes about a week ago) the symptoms began. Recognizing a real problem, I immediately disabled my Internet connection and ran MSE, then, with no relief downloaded Malwarebytes, Hitman Pro, and Spybot Search and Destroy on another computer to a USB thumb drive and ran on the troubled computer. Even disconnected from the Internet, the spawning continued, so I rebooted in Safe Mode. This keeps them from spawning, but booting in Safe Mode with Networking (still physically disconnected) allows them to propagate. I’ve read several other threads here that have the same symptoms, but realize that while many steps are similar, each seems to be resolved at a different step, so would greatly appreciate specialized guidance resolving mine, unless following a generic set of steps (4-Step Viruses/Spyware/Malware Removal Preliminary Instructions or those of BrianD75/Nasty, Nasty iexplore.exe infection-Active) is recommended. My computer has a large number of files on it, so full scans take a long time and create large log files. The upshot of this is that it is best to take scan/repair actions in Safe Mode whenever possible. I will endeavor to follow the steps as precisely as possible, and thank you for any assistance you are able to provide. For the record, I am frustrated and embarrassed that after three-and-a-half decades of computing and being connected to other computers in one form or another (started with a Hayes 300 baud Modem on an Apple II in the late 1970’s) I have – for the first time – been foiled by the wretched hive of scum and computing villainy out there on the ‘net. :-/ Thank you in advance.