What are your OC parameters?
You mention you had a 4.2G OC. That can be arrived at by stock multi (x23) and a BCLK of 183 , or the preferred method of lowering the multiplier to 21 with a BCLK of 200 (preferably with the RAM running at 800 freq. in other words DDR3-1600)
Auto settings on P6T/P6TD boards are usually only good up to around 3.6-3.8G. Once you head into 4+ you probably need to address the QPI/DRAM Core Voltage* ( ~1.3v in my experience with the P6T boards). Asus first revision boards can get a little flaky with long term stable OC's. As red intimated, QPI increases as a result on raising BCLK, and as the QPI increases in bandwidth speed a voltage bump is almost certainly required for stability
I wouldn't rely on OC software for X58 chipsets. The software is damn near fullproof for P55/P67 but has a tendancy to add far too much Vcore for overkill on stability with X58....and of course adding more Vcore also ramps up the need for more chipset voltage.
(* called QPI_VTT w/ Gigabyte/EVGA/DFI boards if you find an OC guide that uses PhoenixAward BIOS nomenclature)
Your best bet would be to either fill out a BIOS template (posted below) with the settings you already have, or reset to default and work incrementally up after raising the QPI/DRAM (and possibly IOH) voltage to ensure stability. I would also manually set Vcore (1.25-1.3v should be sufficient in most cases). You of course have EIST/Speedstep etc disabled I presume?
Code:
P6T Deluxe/P6TD BIOS template
AI Tweaker
****************************
AI Overclock Tuner: AUTO
CPU Ratio Setting: AUTO
Intel (R) SpeedStep TM Tech: ENABLED
BCLK Frequency: 133
PCIE Frequency: 100
DRAM Frequency: AUTO
UCLK Frequency: AUTO
QPI Link Data Rate: AUTO
*******************
DRAM Timing Control
*******************
DRAM CAS Latency: AUTO
DRAM RAS# to CAS# Delay : AUTO
DRAM RAS# PRE Time: AUTO
DRAM RAS# ACT Time: AUTO
DRAM RAS# to RAS# Delay: AUTO
DRAM REF Cycle Time: AUTO
DRAM WRITE Recovery Time: AUTO
DRAM READ to PRE Time: AUTO
DRAM FOUR ACT WIN Time: AUTO
DRAM Back-To-Back CAS# Delay: AUTO
DRAM Timing Mode: AUTO
DRAM Round Trip Latency on CHA: AUTO
DRAM Round Trip Latency on CHB: AUTO
DRAM Round Trip Latency on CHC: AUTO
DRAM WRITE To READ Delay(DD): AUTO
DRAM WRITE To READ Delay(DR): AUTO
DRAM WRITE To READ Delay(SR): AUTO
DRAM READ To WRITE Delay (DD): AUTO
DRAM READ To WRITE Delay (DR): AUTO
DRAM READ To WRITE Delay (SR): AUTO
DRAM READ To READ Delay(DD): AUTO
DRAM READ To READ Delay(DR): AUTO
DRAM READ To READ Delay(SR): AUTO
DRAM WRITE To WRITE Delay(DD): AUTO
DRAM WRITE To WRITE Delay(DR): AUTO
DRAM WRITE To WRITE Delay(SR): AUTO
CPU Voltage: AUTO
CPU PLL Voltage: AUTO
QPI/DRAM Core Voltage: AUTO
IOH Voltage: AUTO
IOH PCIE Voltage: AUTO
ICH Voltage: AUTO
ICH PCIE Voltage: AUTO
DRAM Bus Voltage: AUTO
DRAM DATA REF Voltage on CHA: AUTO
DRAM CTRL REF Voltage on CHA: AUTO
DRAM DATA REF Voltage on CHB: AUTO
DRAM CTRL REF Voltage on CHB: AUTO
DRAM DATA REF Voltage on CHC: AUTO
DRAM CTRL REF Voltage on CHC: AUTO
Load-Line Calibration: AUTO
CPU Differential Amplitude: AUTO
CPU Clock Skew: AUTO
CPU Spread Spectrum: AUTO
IOH Clock Skew: AUTO
PCIE Spread Spectrum: AUTO
Advanced/CPU Configuration
****************************
CPU Ratio Setting: AUTO
C1E Support: Enabled
Hardware Prefetcher: Enabled
Adjacent Cache Line Prefetcher: Enabled
Intel (R) Virtualization Tech: Enabled
CPU TM Function: Enabled
Execute Disable Bit: Enabled
Intel (R) HT Technology: Enabled
Active Processor Cores: ALL
A20M: Disabled
Intel (R) C-State Tech: Enabled
****************************
Express Gate: Disabled
I would also suggest printing off a few copies of the template. Once you have a stable OC -or a number of OC profiles- fill in the values and store them away. If you need to re-input for any reason (usually a BIOS flash which will wipe your profiles and reset to default), the BIOS template settings make resetting the profiles fairly straightforward.
They also come in handy for comparing settings in different profiles- either for benchmarks or for power consumption/heat generation and the various tradeoffs that come with OCing (and OCing via multiplier or baseclock)