I have seen this problem a time or two. And usually when I see it, it is because there is some key that is stuck on the keyboard, or the mouse is stuck in a scrolling motion. I simply hit all buttons on the mouse, and try hitting some of the function keys on the keyboard (shift, alt, ctrl, right, left, up, down). This has usually taken care of the problem for me.
You can also try using a different mouse and keyboard to see if it might be getting old and creating short somehow.