please be more precise on WHY sending fails -- post the actual message seen please.
99.9% of the time this is a malconfigured email client. Port 25 is the default
but sometimes it is specifically changed by the ISP (which one are you using).
the other two issues are:
the isp email server name ( it too can be specific to the ISP: eg: smtp.domain.com, mail.domain.com)
the use of secured login