Programs opening slow

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hi everyone im all new to this so bare with me. my pc a pentium 4 ,2.67ghz 1gb ram all of a sudden the programs are opening slow internet works fine ive cleaned the registry defraged the hd gone to msconfig uncheck the boxes i dont wont to open at start up and its still running slow WHAT THE .... CAN SOMEONE HELP ME WITH THIS
 
How much spare space have you got? Any PC will slow up dramtically at 5% free, but still fairly sure to be a virus etc.
 
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