You don't give us much to work with. Have you tried re-typing the URL for your homepage> Tools> Internet Options> General tab> Homepage section> Use Current?
Have you also deleted the temporary internet files and Cookies? Where are you being redirected to?
Does that restore the homepage? Does it stay on the browser?
I have notices that occasionally a homepage, especially one that has been customized might have a small code change that will prevent it from launching without incident. Deleting the 'tif' and resetting it usually works if this is the cause.