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A good bit of overkill sums it up nicely.The second res is for looks. im planning on 1 asus poseidon graphics cards for now with the evenutuallity of a second. but I have a habit of enjoying a good bit of overkill on what I do. so my cooling I want is a bit on the side of overkill value for my pc even if im not a heavy gamer. granted my CPU im running is an Amd Fx-9370 cpu and the radiators are all made by Xspc.
The dual MCP35X's would suffice for that setup. I'd assume you would go with the two big rads in the bottom of the chassis and the smaller one in the roof. Even with that setup the pumps won't have a problem moving the coolant. Draining and flushing will be fun with a bay mounted reservoir - I'd suggest fitting a couple of quick disconnects (QDC) between the two lower mounted radiators to help out in that regard. Even if you're using the fat RX series rads (though I'd assume it will be the AX or EX series if they are newly acquired) there is ample room to fit the QDC's.
Start a thread if you're after any particular input - or if you just want to show off a build log. This thread is more for the general guide. Good luck.