My Microsoft Outlook file (not Outlook Express) was set up to send/receive messages through one of my ISP’s. I made some minor changes to my Tasks folder on 3/10/08. I then went to Disc Cleanup and compressed my files. Prior to this day I had never checked “Compress Old Files“ for cleanup. I then shut down the computer. When I restarted, I was unable to access Microsoft Outlook at all. If I right clicked on Outlook Icon on the toolbar a box would open asking me to create a new profile with a new profile name. When I hit “cancel” I received this Error Message “No profiles have been created. To create new profile, use the Mail Icon in the Control Panel. When I pressed OK I received another Error Message saying “Cannot start Microsoft Outlook. The server is not available. Contact your administrator if this condition persists.” When I went to the Control Panel and pressed the Mail Icon, there was a box that said “These are the profiles that are set up on this computer.” Inside the box is “empty” showing no profiles at all. I then did a search and located my Outlook file. I attempted to open it to no avail. It had 44,256KB Office Data File. When I attempted to open it I receive this Error Message: Cannot start Microsoft Outlook the command line argument is not valid. Verify the switch you are using. On 3/12/08 I ran Outlook in Safe Mode. I was able to create another file, Outlook 1, which I can use in the future. Of course, I still have the problem of opening my original Outlook file with years of data in it. I hope someone on this site can help me. This is my first posting.