Quake 4 for both PowerPC and Intel powered Macintosh computers has been released by Aspyr Media. Seemingly, the OpenGL-based game engine simplified the port from the PC version, which is normally a fairly daunting task. Aspyr Media has converted numerous PC games to Macintosh platforms over the years.

Duane Johnson, Senior Software Engineer for Aspyr Media, told TG Daily that the Macintosh version will be faithful to the original game. Users can expect similar graphics and framerates; a future patch will bring optimizations that, according to Johnson, will "provide a nice boost when running at lower screen resolutions".