Hi, I am facing a very similar issue to what some have reported , with the dreaded Trojan.sirefef.fy and trojan.Generic being detected in my beloved laptop. The issue is similar to the thread at: http://www.techspot.com/community/topics/trojan-generic-trojan-sirefef.181501/ I have followed the steps listed out too (till ComboFix), and pasted as much information from the runs. Here is a summary: 1. Antivirus Run -BitDefender total security 2013 : kept detecting the Trojans : C:\windows\assembly\GAC_64\Desktop.ini : Trojan.sirefef.fy c:\windows\system32\smss.exe :Trojan.sirefef.fy C:\windows\assembly\GAC_32\Desktop.ini : Trojan.generic. 7552xxx (some numbers) It would keep detecting these Trojans on reboot and give constant warnings. It will claim to have deleted most except 1 or 2 Trojans (sirefef.fy) which simply doesn't get deleted and keeps appearing every time I turn on the laptop . I guess this causes the other trojans to get created/appear every time or something. I have performed the following steps , and I will be copy pasting all the logs information collected : 2. Malwarebytes (didn't detect any infected files) 3. GMER 4. DDS 5. Bootkit Remover 6.aswMBR 7. TDSS Killer 8. FixTDSS 9. ComboFIX Thank you so much in advance for your assistance.