My cousin damaged his motherboard, an Asus Hero Z390e by bending some of the CPU pins (somehow). I spent Saturday back and forth to Microcenter helping him rebuild it and upgrade it to 2TB Crucial MX500 and the PSU from an EVGA 650 to a Corsair 850...which we took back for a EVGA 850 because the Corsair's wires were short.
Almost 12 hours worth of work but I finished.
So now it's a EVGA liquid cooled Core i9 9900k with a 1070, 16GB DDR4 and 2.5TB SSD
I'd say the most imprtant thing to remember about your motherboard is to be careful with the CPU installation. The GPU card installation isn't so difficult.
Properly laying down the CPU, pasting the water cooler and not touching any contacts is the part that bothers me most.
The second issue is ensuring your cables are long enough and having neat cable management so they don't interfere with the motherboard.