I do not think you will need to worry about static build up. As far as I know, nothing will have to be grounded, as this is done through your power supply. Have a look at THIS case. I almost bought this one myself, but then I got a hold of an old dell case that I'm modding.
Plexiglass does not inhibit the expulsion of static. There is no extra ground required besides that which is included in a psu for any case of any type.
I have a waterproof case that i fitted my various components into. After I verified that everything was running, I removed all the fans and filled the case with new engine oil. Now i have Zero cooling issues and Zero dust build up issues! Tada!