Mouse clicking itself

as mentioned in title,
my mouse is clicking itself every few minutes,
i try to change a mouse but same problem happened,
i wonder is it something wrong with my motherboard,
im using a usb mouse and i try to change to another usb port but same thing happened
any idea about what's the problem??
thanks
 
Disconnect your mouse and see if it keeps clicking to check if it is a joke virus but off from that it may be a false contact or maybe a programmable mouse(?), what model/brand is it?
 
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