The GeForce GTX 480 left the Radeon HD 5870 behind by a 14% performance margin when testing with Company of Heroes Opposing Fronts. It was even 5% faster than the GTX 295 and 16% faster than the Radeon HD 4870 X2. Just one single card configuration beat the GeForce GTX 480 at 2560x1600, and that was the dual-GPU Radeon HD 5970.

Nvidia's new flagship was also very fast when testing Crysis Warhead, averaging 38fps at 2560x1600. This was enough to match the performance of the GTX 295, making it around 31% faster than the Radeon HD 5870 and 19% faster than the Radeon HD 4870 X2. Once again, the only single card configuration to beat the GTX 480 was the Radeon HD 5970.