Ntfs file allocation size and defragmentation

Danny101

TS Evangelist
I'm reworking an USB 2.0 hard drive for backup. I've been looking to optimize it with multiple partitions and NTFS file allocation sizes such as standard for small files and larger clusters for music and video files. It's come to my attention that Windows defrag can't handle non-standard NTFS cluster sizes, so are there defrag programs that can?
 

Danny101

TS Evangelist
I've come to the conclusion that it's 64KB for media such as pictures , music, and video, and 4KB for everything else. If I could go 64KB for everything, I would because most files are more than that anyway. With the supposed wasted space, I can hardly see that as an issue anymore since data files are so blown up and hard drive space is a dime a dozen. Also, SSD drives don't utilize defrag programs, so how does TRIM fair with 64KB cluster sizes?