Hello All, I have been fighting probable virus/malware infection for the last week which has got progressively worse. The computer in question will now only partially complete the start-up sequence, even in safe mode. The computer gets as far as the screen where you can choose to log in as the Administrator or my regular Username, however the mouse pointer appears frozen and cannot be moved. I have tried the mouse-keys solution to attempt to get further into the start-up sequence, without any success. My computer has Windows XP Service Pack 3 installed. The first problem to manifest itself was an error box coming up on every start-up which indicated a problem with a file called "googleupdate.exe" being unable to write to memory or similar. I subsequently installed both Malwarebytes Anti-Malware and the Ad Aware free package and ran those, which indicated some malware and supposedly removed the infections. My browser history was indicating dozens of visits to pages on a website called "meebo.com" as well as suspicious looking processes in the Task Manager window. The computer would become progressively more slugish throughout the day. Once the Malwarebytes and Ad Aware packages had done their "cleaning" I was getting clean scan logs, the visits to Meebo stopped and the processes list appeared clean of suspicious activity. Things appeared to be fine for a couple of days and I believed I had resolved the issue. However, then the computer started behaving sluggishly again so I installed a third package, SpyHunter 4. That scan indicated a "virus.patchload.o" infection to files associated with my ATI graphics card software and recommended removal. As this was the free SpyHunter pacakge, the files in question were not removed. The scans with Malwarebytes and Ad Aware were coming up clean. Concerned that I was leaking sensitive info to the internet, I disconnected my broadband cable and attempted a reboot of the computer. Which brings me to the start-up problems as described at the top. One other thing, my computer is home built and does not have a FDD or CD drive currently installed due to internal case issues. I can plug a CD drive in if necessary. Any assistance gratefully received and appreciated.